产品货号：
Z33865
中文名称：
SAPAP1/DLGAP1抗体
英文名称：
Anti-SAPAP1/DLGAP1 Antibody (Clone#3G4)
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SAPAP1/DLGAP1 Antibody (Clone#3G4) |
| 指标别名 | DLG associated protein 1;DAP-1;DAP-1-ALPHA;DAP-1-BETA;DAP1A;DLGAP1B;GKAP;SAPAP1;DLGAP1;hGKAP;SAPAP1 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,IF,ELISA |
| 基因名称 | DLGAP1 |
| 克隆号 | 3G4 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG |
| 免疫原 | Purified recombinant fragment of human SAPAP1 expressed in E.Coli. |
| 计算分子量 | 109KD |
| 成分 | Ascitic fluid containing 0.03% sodium azide. |
| 纯化方式 | Affinity purification |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | -20℃可保存1年，短期保存或频繁使用请置于4℃，可保存一个月，避免反复冻融。 |
| 背景资料 | Disks large-associated protein 1 (DAP-1),also known as guanylate kinase-associated protein (GKAP),is a protein that in humans is encoded by the DLGAP1 gene.The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses.Glutamate is released from the presynaptic membrane into the synaptic cleft.Across the synaptic cleft glutamate binds to both ion channels and metabotropic glutamate receptors at the postsynapse,which expedite downstream signalling in the neuron.The postsynaptic density,a highly specialized matrix,which is attached to the postsynaptic membrane,controls this downstream signalling.The postsynaptic density also resets the synapse after each synaptic firing.It is composed of numerous proteins including a family of Discs large associated protein 1,2,3 and 4 (DLGAP1-4) that act as scaffold proteins in the postsynaptic density.They link the glutamate receptors in the postsynaptic membrane to other glutamate receptors,to signalling proteins and to components of the cytoskeleton.With the central localisation in the postsynapse,the DLGAP family seems to play a vital role in synaptic scaling by regulating the turnover of both ionotropic and metabotropic glutamate receptors in response to synaptic activity.DLGAP family has been directly linked to a variety of psychological and neurological disorders. |
| Uniprot ID | O14490 |
| 基因名全称 | Disks large-associated protein 1 |
| 蛋白名全称 | Disks large-associated protein 1 |
| 推荐稀释比 | WB 1:500～1:2000 IHC 1:200～1:1000 IF 1:200～1:1000 ELISA 1:10000 |
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